Persone trovate
Generoso
Bevilacqua
Prof. Ordinario
presso il Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia
Settore scientifico disciplinare Anatomia Patologica MED/08
Settore scientifico disciplinare Anatomia Patologica MED/08
Recapito
telefono: 050 992889fax: 050 992706
e-mail:
indirizzo: Divisione di Anatomia Patologica - via Roma, 57 56126 Pisa
Cariche
Presidente di Programma Dottorati in Oncologia Sperimentale e MolecolareDirettore della Scuola di Dottorato Scuola di Dottorato in Scienze Biologiche e Molecolari
Curriculum
Please, see "Informazioni addizionali"Informazioni addizionali
A. Degrees
- Medicine, University of Pisa, 1971, cum laude- Specialty in Pathology, Catholic University, Rome, 1976, cum laude
- Collegio Medico, Scuola Normale Superiore and Scuola Sant’Anna, Pisa, 1971
B. Present positions
- Professor of Pathology, University of Pisa- Director, Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and Pisa University Hospital
- Director, BIOS – Research Doctorate School in BIOmolecular Sciences, University of Pisa
C. Present scientific responsibilities
- President, Italian College of Pathologists - the Association of Professors of Pathology- Executive Committee, European Society of Pathology - ESP
- Chairman, European Group for Molecular Pathology, European Society of Pathology - ESP
- Education Committee, European Society of Pathology
- Board, European Association of Pathology Chairs and Program Directors - EAPCP
- Chairman, Committee for Testing and Certification, European Association of Pathology Chairs and Program Directors - EAPCP
- Chairman, Italian Group for Molecular Pathology, Italian Society of Pathology - SIAPEC
- Chairman, “Medical Sciences” Scientific Committee, University of Pisa
- Expert Committee in Pathology, BBMRI – Biobanking and Bio-Molecular Resources Research Infrastructures in Europe
- Board, Senologic Specialties Committee, Senologic International Society - SIS
- UICC, International Union Against Cancer, TNM Committee, Italian Division
- Coordinator, “Genetic Risk” Project Project “, Tuscany Region
- Board, Istituto Superiore di Oncologia, Ministry for University Research, Italy
- “Genetic and Familiar Risk of Tumors” Committee, Italian Cancer League
- Scientific Advisor, Verona University Consortium, Italy
- Editorial Board, American Journal of Pathology
- Editorial Board, Source Code for Biology and Medicine
- Editorial Board, Bioscience Trends
D. Previous positions
- 1971-1977 Assistant Professor, Institute of Pathology, University of Pisa- 1977-1989 Vice-Director, Institute of Pathology, University of Pisa
- 1989-1992 Director, II Division of Pathology, Institute of Pathology, University of Pisa
- 1992-1996 Director, Institute of Pathology, University of Pisa
- 1997-1999 Director, Department of Oncology, University of Pisa
- 1997-2006 Director, Post-graduate School in Oncology, University of Pisa
E. Previous scientific responsibilities
- Coordinator, AIRC National Project “Italian Consortium for Hereditary Breast and Ovarian Cancer”- Director, CNR-MIUR National Strategic Project “Molecular Diagnosis in Oncology”
- Coordinator, Invasion and Metastasis Study Group, Italian Cancer Society – SIC
- Chairman, Italian Group for Breast and Ovarian Hereditary Tumors, Italian Cancer Society – SIC
- Board of Governors, International Association for Breast Cancer Research – IABCR
- Board, European Clinical Collaborative Group on Familial Breast Cancer
- Board, Italian Society of Pathology – SIAPEC
- Board, Italian Cancer Society – SIC
- Board, Italian Society for Applied and Basic Cell Kinetics - SICCAB
- Board, Italian Group for Radio-immunoguided Surgery and Immunoscintigraphy - GISCRIS
- National Committee for Biosafety and Biotechnologies, Presidency of the Council of Ministers, Italy: Working Groups on “Genetic Screening of Populations” and “Biosafety”
- Scientific Advisor, “Comel” Foundation, Italy
- Scientific Advisor, Italian Foudation for Neuroblastoma
- Editorial Board, Diagnostic Molecular Pathology (Am J Surg Pathol, part B
- Editorial Board, International Journal of Biological Markers
F. Training
- 1970: Department of Pathology, Grimsby General Hospital, Grimsby, UK- 1972: Departments of Pathology: National Heart Hospital, London; Brompton Hospital, London; London Chest Hospital; Children Hospital, London; University of Edinburgh; University of Aberdeen; Western Infirmary, Glasgow, UK
- 1980: Laboratory of Electron Microscopy, Netherlands Cancer Institute, Amsterdam, The Netherlands
G. Scientific research abroad
- February 1986 – February 1988: Tumor Invasion and Metastasis Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USAH. Patents
- co-author, USA patent n. 5,049,662, about NM23 geneI. Reviewer for Governmental and Scientific Institutions
- Catalan Agency for Health Technology Assessment and Research, Spain- Dutch Cancer Society, The Netherlands
- Fonds National de la Recherche Scientifique, Belgium
- FWF, Austrian Science Fund, Austria
- Institut National du Cancer, France
- International Union Against Cancer - UICC
- Israel Science Foundation, Israel
- Ministry of Health, Jordan
- University of Manchester, UK
- AIRI, Italian Association for Industrial Research
- Italian Ministry of University and Research
- Foundation “Savings Bank” of Padua
- Foundation “Savings Bank” of Verona
- University of Padua
- University of Siena
J. Reviewer for Scientific Journals
Biochimica et Biophysica Acta; Breast Cancer Research; British Journal of Cancer; Cancer; Cancer Letters; Cancer Research; Clinical Cancer Research; Diagnostic Molecular Pathology; European Journal of Cancer; European Journal of Obstetrics and Gynecology and Reproductive Biology; European Journal of Oncology; European Journal of Pediatrics; Experimental Cell Research; International Journal of Cancer; International Journal of Biological Markers; Invasion and Metastasis; Journal of Clinical Pathology; Journal of Molecular Medicine; Journal of Pathology; Melanoma Research; Virkows Archiv; World Journal of GastroenterologyK. Main scientific interests
- Molecular Pathology- Experimental Oncology
- Breast Cancerogenesis
- Oncogenetics
- Hereditary Tumors
L. Publications: 1-22
1) Bevilacqua G: Congenital mitral regurgitation due to 'posterior reinsertion' of chordae tendineae. Br Heart J 36: 520-524, 19742) Barsotti G, Bevilacqua G, Morelli E, Cappelli P, Balestri PL, Giovannetti S: Toxicity arising from guanidine compounds: role of methylguanidine as a uremic toxin. Kidney Int 3: 299-301, 1975
3) Bevilacqua G, Fornaciari G: Clinico-pathological correlations in a case of traumatic pan-hypopituitarism. Acta Neuropathol 31: 171-177, 1975
4) Bevilacqua G, Mariani M: Clinico-pathological correlations in a case of primary angiosarcoma of the pericardium. Eur J Cardiol 2: 495-504; 1975
5) Bevilacqua G, Toni G, Tuoni M: A case of cavernous haemangioma of the spleen. Tumori 62: 485-492, 1976
6) Martino E, Bevilacqua G, Nardi M, Macchia E, Pinchera A: Metastatic cervical carcinoma presenting as primary thyroid cancer. Case report. Tumori 63: 25-30, 1977
7) Bistocchi M, Bevilacqua G, Nuti M: Quantitative determination of mammary tumor virus in individual samples of mouse milk. Tumori 63: 525-534, 1977
8) Bevilacqua G, Sarnelli R: Ganglioglioma of the spinal cord. A case with a long survival. Acta Neuropathol 48: 239-242, 1979
9) Bevilacqua G, Giusti C, Bargagna M: UHL's anomaly in young adult. Clinico-pathological data and review of the literature. Pathologica 72: 413-420, 1980
10) Bevilacqua G, Camici P, L'Abbate A: Spontaneous dissecting aneurysm of the aorta in a dog. Vet Pathol 18: 273-275, 1981
11) Bevilacqua G: Cytogenesis of murine mammary tumors in BALB/cfC3H and BALB/cfRIII strains. Histochemistry 72: 49-53, 1981
12) Gabrielli F, Bevilacqua G, Salvini M: Histones of human lung carcinoma and human lung tissue. Analysis by two-dimensional electrophoresis. Tumori 67: 105-108, 1981
13) Colizzi V, Campa M, Garzelli C, Toca L, Bevilacqua G, Falcone G: Impairment of cell-mediated immunity in Pseudomonas aeruginosa pyelonephritis: lack of suppressor cell activity in vivo. Med Microbiol Immunol 171: 123-133, 1982
14) Bevilacqua G: Unusual findings of viral production (MuMTV) in murine mammary tumors (BALB/cfC3H). Exp Mol Pathol 39: 271-281, 1983
15) Bevilacqua G, Mariotti S, Castagna M, Marcocci C, Di Coscio GC, Martino E: Cutaneous metastasis of a radiation-associated thyroid medullary carcinoma. J Endocrinol Invest 7: 653-657, 1984
16) Bevilacqua G, Abadessa A, Consolini R, Frijia M, Nardi M, Macchia P: Bone marrow necrosis foreshadowing acute lymphoid leukemia. Am J Pediatr Hematol Oncol 7: 228-233, 1985
17) Falchi E, Benassi A, Pisani P, Bevilacqua G, Mariani G: A new microwave scanning system for imaging superficial organs. J Nucl Med Allied Sci 29: 275-282, 1985
18) Bevilacqua G, Marchetti A: Mouse Mammary Tumor Virus (MMTV) morphology in the gastrointestinal lumen of suckling mice. In: Gallo RC, Stehelin D, Varnier OE: Retroviruses and human pathology. Humana Press, 139-144, 1985
19) Pedrinelli R, Graziadei L, Taddei S, Lenzi M, Magagna A, Bevilacqua G, Salvetti A: A renin-secreting tumor. Nephron 46: 380-385, 1987
20) Steeg PS, Bevilacqua G, Kopper L, Thorgeirsson UP, Talmadge JE, Liotta LA, Sobel ME: Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst 80: 200-204, 1988
21) Steeg PS, Bevilacqua G, Pozzatti R, Liotta LA, Sobel ME: Altered expression of NM23, a gene associated with low tumor metastatic potential, during adenovirus 2 Ela inhibition of experimental metastasis. Cancer Res 48: 6550-6554, 1988
22) Fornaciari G, Tornaboni D, Castagna M, Bevilacqua G, Tognetti A: Variole dans une momie du XVIe siecle de la basilique de S. Domenico Maggiore a Naples: etude immunohistochimique, ultrastructurelle et biologie moleculaire. J Paleopathol 4: 97-100, 1988
L. Publications: 23-40
23) Bevilacqua G, Marchetti A, Biondi R: Ultrastructural features of the intestinal absorption of mouse mammary tumor virus in newborn BALB/cfRIIImice. Gastroenterology 96: 139-145, 198924) Bevilacqua G, Bruno J, Biondi R: Submacroscopical analysis of the human breast with ultrastructural correlations: a method. Surgical Pathol 2: 163-169, 1989
25) Bevilacqua G, Sobel ME, Liotta LA, Steeg PS: Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential. Cancer Res 49: 5185-5190, 1989
26) Steeg PS, Bevilacqua G, Rosengard A, Cioce V, Liotta LA: Altered gene expression in tumor metastasis: the NM23 gene. In: Schirrmacher V, Schwartz-Albiez R: Cancer metastasis. Molecular and cellular biology, host immune responses and perspectives for treatment. Springer Verlag, Heidelberg, 48-52, 1989
27) Steeg PS, Bevilacqua G, Sobel ME, Liotta L: Invasion and Metastasis. In: Cossman J, Molecular genetics in cancer diagnosis. Elsevier, NY, 105-112, 1990
28) Bevilacqua G: Tumor cell heterogeneity and metastasis. Pathol Biol 38: 857-858, 1990
29) Bevilacqua G: NM23 gene expression and human breast cancer metastases. Pathol Biol 38: 774-775, 1990
30) Danesi R, Marchetti A, Bernardini N, La Rocca RV, Bevilacqua G, Del Tacca M: Cardiac toxicity and antitumor activity of 4'-deoxy-4'-iodo-doxorubicinol. Cancer Chemother Pharmacol 26: 403-408, 1990
31) Macchiarini P, Danesi R, Mariotti R, Marchetti A, Fazzi P, Bevilacqua G, Mariani M, Giuntini C, Del Tacca M, Angeletti CA: Phase II study of high-dose epirubicin in untreated patients with small-cell lung cancer. Am J Clin Oncol 13: 302-307, 1990
32) Macchiarini P, Chella A, Ducci F, Rossi B, Testi C, Bevilacqua G, Angeletti CA: Neoadjuvant chemotherapy, surgery, and postoperative radiation therapy for invasive thymoma. Cancer 68: 706-713, 1991
33) Steeg PS, Bevilacqua G, Sobel ME, Liotta LA: Identification and characterization of differentially expressed genes in tumor metastasis: the nm23 gene. Basic Life Sci 57: 355-360, 1991
34) Revoltella RP, Beffy P, Vigneti E, Andreini I, Dal Monte M, Garibotti M, Bevilacqua G: Hybridoma monoclonal antibodies against the odorant binding protein. J Immunol Res 3: 129-138, 1991
35) Bevilacqua G, Caligo MA: Suppressor genes in tumor progression. In: Brandi ML, White R: Hereditary tumors. Raven Press, NY, 199-205, 1991
36) Steeg PS, Bevilacqua G, Sobel ME, Liotta LA: Identification and characterization of differentially expressed genes in tumor metastasis: the NM23 gene. In: Sudilowsky O, Pitot HC, Liotta LA: Boundaries between promotion and progression during carcinogenesis. Plenum Press, NY & London, 355-361, 1991
37) Fornaciari G, Tornaboni D, Caligo MA, Cipollini G, Bevilacqua G: La mummia dei Musei di Varese. In: Banchieri DG: La mummia dei Musei di Varese. Comune di Varese, 18-21, 1992
38) Fornaciari G, Castagna M, Viacava P, Tognetti A, Bevilacqua G, Segura EL: Chagas' disease in Peruvian Inca mummy. Lancet 339: 128-129, 1992
39) Varesco L, Caligo MA, Simi P, Black DM, Nardini V, Casarino L, Rocchi M, Ferrara G, Solomon E, Bevilacqua G: The NM23 gene maps to human chromosome band 17q22 and shows a restriction fragment length polymorphism with BglII. Genes Chromosomes Cancer 4: 84-88, 1992
40) Caligo MA, Cipollini G, Cope Di Valromita A, Bistocchi M, Bevilacqua G: Decreasing expression of NM23 gene in metastatic murine mammary tumors of viral etiology (MMTV). Anticancer Res 12: 969-973, 1992
L. Publications: 41-56
41) Mariani G, Cei A, Giuliani L, Baranowska-Kortylevicz J, Collecchi P, Di Stefano R, Di Luca L, Viacava P, D’Elia F, Guadagni A, Meucci G, Salvadori PA, Van Den Abbeele AD, Bevilacqua G, Mosca F, Adelstein SJ, Kassis AI: Tumor targeting potential and metabolism in patients with gastrointestinal or breast cancer. J Nuclear Biol Med 36: 154-157, 199242) Carmassi F, Morale M, Puccetti R, Pistelli F, Palla R, Bevilacqua G, Viacava P, Antonelli A, Mariani G: Efficacy of intravenous immunoglobulin therapy in a case of autoimmune-mediated chronic active hepatitis. Clin Exp Rheumatol 10: 13-17, 1992
43) Siciliano G, Rossi B, Angelini C, Martinuzzi A, Carrozzo R, Bevilacqua G, Viacava P, Federico A, Fabrizi GM, Muratorio A: Variability of the expression of muscle mitochondrial damage in ocular mitochondrial myopathy. Neuromuscul Disord 2: 397-404, 1992
44) Siciliano G, Viacava P, Rossi B, Andreani D, Muratorio A, Bevilacqua G: Ocular myopathy without ophthalmoplegia can be a form of mitochondrial myopathy. Clin Neurol Neurosurg 94: 133-141, 1992
45) Basolo F, Fugazzola L, Fontanini G, Elisei R, Pepe S, Bevilacqua G, Pinchera A, Pacini F: Markers of cell proliferation as prognostic factors in differentiated thyroid cancer. Int J Oncol 3: 1077-1081, 1993
46) Mariani G, Cei A, Collecchi P, Baranowska-Kortylevicz J, Van Den Abbeele AD, Di Luca L, Di Stefano R, Viacava P, Ferdeghini M, Di Sacco S, Salvadori PA, Bevilacqua G, Adelstein SJ, Mosca F, Kassis AI: Tumor targeting in vivo and metabolic fate of 5-(Iodine-125)-Iodo-2’-Deoxyuridine following intratumoral injection in patients with colorectal cancer. J Nuclear Med 34: 1175-1183, 1993
47) Mariani G, Collecchi P, Giuliani L, Baranowska-Kortylevicz J, Di Luca L, Meucci G, Viacava P, Van Den Abbeele AD, Salvadori PA, Di Sacco S, Adelstein SJ, Bevilacqua G, Kassis AI: Tumor targeting potential and metabolism of 5-(125-I)-Iodo-2’-Deoxyuridine injected intratumorally in patients with breast cancer. Ann NY Acad Sci 698: 204-211, 1993
48) Danesi R, Agen C, Grandi M, Nardini V, Bevilacqua G, Del Tacca M: 3'-Deamino-3'-(2-methoxy-4-morpholinyl)-doxorubicin (FCE 23762): a new anthracycline derivative with enhanced cytotoxicity and reduced cardiotoxicity. Eur J Cancer 29: 1560-1565, 1993
49) Bafico A, Varesco L, De Benedetti L, Caligo MA, Gismondi V, Sciallero S, Aste H, Ferrara GB, Bevilacqua G: Genomic PCR-SSCP analysis of the metastasis associated NM23-H1 (NME1) gene: a study on colorectal cancer. Anticancer Res 13: 2149-2154, 1993
50) Caligo MA, Ghimenti C, Bevilacqua G: NM23.H1 loss of heterozygosity in human mammary carcinomas. Definition of a deletion map on chromosome 17q. Ann N Y Acad Sci 698: 136-142, 1993
51) Pacini F, Fugazzola L, Bevilacqua G, Viacava P, Nardini V, Martino E: Multiple endocrine neoplasia type 2A and cutaneous lichen amyloidosis: description of a new family. J Endocrinol Invest 16: 295-296, 1993
52) Campani D, Cecchetti D, Bevilacqua G: Immunocytochemical p53 detection by microwave oven heating of routinely formalin-fixed paraffin sections. J Pathol 171: 151-152, 1993
53) Squartini F, Bevilacqua G, Conte PF, Surbone A: Breast Cancer, from Biology to Therapy. Annals of the New York Academy of Sciences, vol. 698, 1993
54) Bevilacqua G: Oncogeni. In: Squartini F: Anatomia Patologica. Ambrosiana, 167-170, 1993
55) Bevilacqua G: Sistema Nervoso Centrale e Periferico. In: Squartini F: Anatomia Patologica. Ambrosiana, 549-631, 1993
56) Bevilacqua G, Viacava P: Muscoli scheletrici. In: Squartini F: Anatomia Patologica. Ambrosiana, 1327-1340, 1993
L. Publications: 57-71
57) Marchetti P, Giannarelli, Villani G, Andreozzi M, Cruschelli L, Cosimi S, Viacava P, di Carlo A, Navalesi R, Bevilacqua G: Collagenase distension, two-step sequential filtration, and histopaque gradient purification for consistent isolation of pure pancreatic islets from the market-age (6-month-old) pig. Transplantation 57: 1532-1535, 199458) Pacini F, Pinchera A, Mancusi F, Pollina L, Fontanini G, Bevilacqua G, Cartei F, Miccoli P, Basolo F: Anaplastic tyroid carcinoma: a retrospective clinical and immunohistochemical study. Oncol Rep 1: 921-925, 1994
59) Viacava P, Giannarelli R, Marchetti P, Castagna M, Naccarato G, Villani G, Cosimi S, Andreozzi M, Cruschelli L, Coppelli A, Bevilacqua G, Navalesi R: Morphologic characterization of isolated porcine and bovine islets of Langerhans. Transplantation Proc 26: 1130-1131, 1994
60) Caligo MA, Grammatico P, Cipollini G, Varesco L, Del Porto G, Bevilacqua G: A low NM23.H1 gene expression identifyjng high malignancy human melanomas. Melanoma Res 10: 179-184, 1994
61) Pietrabissa A, Di Stefano R, Collecchi P, Campanella PG, Della Capanna S, Scarcello E, Turini L, Bevilacqua G, Mosca F: Effect of cyclosporine-A pretreatment on lidocaine metabolite formation in the regenerating rat liver. Transplantation Proc 26: 2908-2909, 1994
62) Fontanini G, Bigini D, Vignati S, Ribecchini A, Angeletti CA, Basolo F, Pingitore R, Bevilacqua G: Human non small cell lung cancer: p53 protein accumulation is an early event and persists during metastatic progression. J Pathol 173: 23-31, 1994
63) Fornaciari G, Castagna M, Tognetti A, Viacava P, Bevilacqua G: New observations on a case of treponematosis (venereal syphilis?) in an italian mummy of the 16th century. In: Dutour O et al, “L’origine de la syphilis en Europe: avant ou après 1493?. Ed Errance, Toulon-Paris, 206-210, 1994
64) Marchetti A, Buttitta F, Pellegrini S, Lori A, Bertacca G, Bevilacqua G: Absence of somatic mutations in the coding region of the WAF1/CIP1 gene in lung, breast and ovarian carcinomas. A polymorphism at codon 31. Int J Oncol 6: 187-189, 1995
65) Marchetti A, Buttitta F, Pellegrini S, Merlo G, Chella A, Angeletti CA, Bevilacqua G: mdm2 gene amplification and overexpression in non-small cell lung carcinomas with accumulation of the p53 protein in the absence of p53 gene mutations. Diag Mol Pathol 4: 93-97, 1995
66) Fontanini G, Vignati S, Bigini D, Mussi A, Lucchi M, Angeletti CA, Basolo F, Bevilacqua G: bcl-2 protein: a prognostic factor inversely correlated to p53 in non small cell lung cancer. Br J Cancer 72: 1003-1007, 1995
67) Fontanini G, Vignati S, Bigini D, Mussi A, Angeletti CA, Pingitore R, Basolo F, Bevilacqua G: Epidermal Growth Factor Receptor (EGFR) expression in non-small cell lung carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype. Eur J Cancer 2: 178-183, 1995
68) Lencioni R, Bartolozzi, Caramella, Paolicchi A, Carrai M, Maltinti G, Capria A, Tafi A, Conte PF, Bevilacqua G: Treatment of small hepatocellular carcinoma with percutaneous ethanol injection. Analysis of prognostic factors in 105 western patients. Cancer 76: 1737-1746, 1995
69) Caligo MA, Cipollini G, Fiore L, Calvo S, Basolo F, Collecchi P, Ciardiello F, Pepe S, Petrini M, Bevilacqua G: NM23 gene expression correlates with cell growth rate and S-phase. Int J Cancer 60: 837-842, 1995
70) Viacava P, Castagna M, Bevilacqua G: Absence of neuroendocrine cells in fetal and adult mammary glands. Are neuroendocrine breast tumours real neuroendocrine tumours? The Breast 4: 143-146, 1995
71) Viacava P, Naccarato AG, Nardini V, Bevilacqua G: Breast carcinoma with osteoclast-like giant cells: immunohistochemical and ultrastructural study of a case and review of the literature. Tumori 81: 135-141, 1995
L. Publications: 72-86
72) Marchetti A, Buttitta F, Girlando S, Dalla Palma P, Pellegrini S, Doglioni C, Bevilacqua G, Barbareschi M: mdm2 gene alterations and mdm2 protein expression in breast carcinomas. J Pathol 175: 31-38, 199573) Fontanini G, Bigini D, Vignati S, Basolo F, Mussi A, Lucchi M, Angeletti CA, Harris HL, Bevilacqua G: Microvessel count predicts metastatic disease and survival in non-small cell lung cancer. J Pathol 177: 57-63, 1995
74) Lenziardi M, Viacava P, Fiorini I, Castagna M, Nardini V, Pollina L, De Negri F, Goletti O, Di Coscio G, Bevilacqua G: Presence of endothelin-1 in the normal and pathological human thyroid. J Endocrinol Invest 18: 336-340, 1995
75) Marchetti A, Bevilacqua G: Immunogold-silver staining of viral antigens in infected cells. In: Immunogold-silver staining: methods and applications, Hayat MA Ed, Chapter 18, p. 275-288, CRC Press, Boca Roton, Florida, 1995
76) Bosari S, Marchetti A, Buttitta F, Graziani D, Borsani G, Loda M, Bevilacqua G, Coggi G: Detection of p53 mutations by single-strand conformation polymorphism (SSCP) gel electrophoresis. A comparative study of radioactive and non-radioactive silver-stained SSCP analysis. Diag Mol Pathol 4: 249-255, 1995
77) Mariani M, Petronio AS, Manes MT, Morelli M, Squecco D, Nardini V, Bevilacqua G, Ceccherini-Nelli L: Detection of enteroviral infection of myocardial tissues by polymerase chain reaction (PCR). Clin Microbiol Infect 2: 109-114, 1996
78) Fontanini G, Vignati S, Bigini D, Lucchi M, Mussi A, Basolo F, Angeletti CA, Bevilacqua G: Neoangiogenesis: a putative marker of malignancy in non small cell lung cancer (NSCLC) development. Int J Cancer 67: 615-619, 1996
79) Fontanini G, Vignati S, Bigini D, Mussi A, Lucchi M, Chinè S, Angeletti CA, Bevilacqua G: Recurrence and death in non small cell lung carcinomas: a prognostic model using pathological parameters, microvessel count and gene protein products. Clinical Cancer Res 2: 1067-1075, 1996
80) Angeletti CA, Lucchi M, Fontanini G, Mussi A, Chella A, Vignati S, Bevilacqua G: Prognostic significance of tumoral angiogenesis in completely resected patients with late-stage lung cancer (Stage IIIa-N2). Impact of adjuvant therapies in a subset of patients at high risk of recurrence. Cancer 78: 409-415, 1996
81) Barbareschi M, Caffo O, Doglioni C, Fina P, Marchetti A, Buttitta F, Leek R, Morelli R, Leonardi E, Bevilacqua G, Dalla Palma P, Harris A.R. p21WAF1 immunohistochemical expression in breast carcinoma: correlations with clinicopathologic data, oestrogen receptor status, MIB1 expression, p53 gene and protein alterations, and relapse-free survival. Br. J. Cancer 74: 208-215, 1996
82) Collecchi P, Giannessi PG, Baldini E, Naccarato AG, Passoni A, Bevilacqua G, Conte PF: Effects of primary chemotherapy on biological parameters of locally advanced breast cancer. Ann NY Acad Sci 784: 419-426, 1996
83) Caligo MA, Cipollini G, Petrini M, Valentini P, Bevilacqua G: Down regulation of NM23.H1, NM23.H2 and c-myc genes during differentiation induced by 1,25 dihydroxyvitamin D3. Leukemia Res 20: 161-167, 1996
84) Caligo MA, Ghimenti C, Cipollini G, Ricci S, Brunetti I, Marchetti V, Olsen R, Neuhausen S, Shattuck-Eidens D, Conte PF, Skolnick M, Bevilacqua G: BRCA1 germ line mutational spectrum in italian families from Tuscany: a high frequency of novel mutations. Oncogene 13: 1483-1488, 1996
85) De Benedetti V, Radice P, Mondini P, Spatti G, Conti A, Ileni M, Cipollini G, Caligo MA, Bevilacqua G, Pilotti S, Pierotti M: Screening for mutation in exon 11 of the BRCA1 gene in 70 breast and ovarian cancer patients by PTT. Oncogene 13: 1353-1357, 1996
86) Caligo MA, Ghimenti C, Collecchi P, Viacava P, Campani D, Bevilacqua G: A deletion map of chromosome 17q in sporadic human mammary carcinomas: correlation with pathological parameters. Int J Oncol 8: 1003-1010, 1996
L. Publications: 87-101
87) Gadducci A, Ferdeghini M, Buttitta F, Fanucchi A, Annichiarico C, Prontera C, Bevilacqua G, Genazzani AR: Preoperative serum antibodies against the p53 protein in patients with ovarian and endometrial cancer. Anticancer Res 16: 3519-3523, 199688) Marchetti A, Pellegrini S, Bevilacqua G, Fornaciari G: K-ras mutations in the tumour of Ferrante I of Aragon, King of Naples (1431-1494). The Lancet 347: 1272, 1996
89) Pollina L, Pacini F, Fontanini G, Bevilacqua G, Basolo F: bcl-22, p53 and proliferating cell nuclear antigen expression is related to the degree of differentiation in thyroid carcinomas. Br J Cancer 73: 139-143, 1996
90) Basolo F, Pollina L, Pacini F, Fontanini G, Ménard S, Castronovo V, Bevilacqua G: Expression of the Mr 67,000 laminin receptor is an adverse prognostic indicator in human thyroid cancer: an immunohistochemical study. Clin Cancer Res 2: 1777-1780, 1996
91) Marchetti A, Doglioni D, Barbareschi M, Buttitta F, Pellegrini S, Bertacca G, Chella A, Angeletti CA, Bevilacqua G: p21 mRNA and protein expression in non-small cell lung carcinomas: evidence of p53-independent expression and association with tumoral differentiation. Oncogene 12: 1319-1324, 1996
92) Marchetti A, Buttitta F, Pellegrini S, Chella A, Bertacca G, Filardo A, Tognoni V, Ferreli F, Signorini E, Angeletti CA, Bevilacqua G: Bronchioloalveolar lung carcinomas: K-ras mutations are constant events in the mucinous subtype. J Pathol 179: 254-259, 1996
93) Marchetti A, Buttitta F, Pellegrini S, Bertacca G, Carnicelli V, Chella A, Angeletti CA, Bevilacqua G: Alterations of p16 (MTS1) in node positive non-small cell lung carcinomas. J Pathol 181: 178-182, 1997
94) Sozzi G, Sard L, De Gregorio L, Marchetti A, Musso K, Buttitta F, Tornielli S, Pellegrini S, Veronese ML, Manenti G, Incarbone M, Chella A, Angeletti CA, Pastorino U, Huebner K, Bevilacqua G, Pilotti S, Croce CM, Pierotti MA: Association between cigarette smoking and FHIT alterations in lung cancer. Cancer Res 57: 1121-1123, 1997
95) Palego L, Marazziti D, Rotondo A, Batistini A, Lucacchini A, Naccarato AG, Bevilacqua G, Borsini F, Ladinsky H, Cassano GB: Further characterisation of 3H8-hydroxy-2-(DI-N-propylamino) tetralin bynding sites in human brain postmortem. Neurochem Int 30: 149-157, 1997
96) Buttitta F, Marchetti A, Gadducci A, Pellegrini S, Morganti M, Carnicelli V, Cosio S, Gagetti O, Genazzani AR, Bevilacqua G: p53 alterations are predictive of chemoresistance and aggressiveness in ovarian carcinomas: a molecular and immunohistochemical study. Br J Cancer 75: 230-235, 1997
97) Buttitta F, Athanassiadou S, Marchetti A, Gadducci A, Bellina S, Cosio S, Mancini F, Genazzani AR, Bevilacqua G: p53 nuclear accumulation in adenomatous hyperplasia and stage I endometrioid carcinoma. Oncol Rep 4: 315-318, 1997
98) Caligo MA, Cipollini G, Berti A, Viacava P, Collecchi P, Bevilacqua G: NM23 gene expression in human breast carcinomas: loss of correlation with cell proliferation in the advanced phase of tumor progression. Int J Cancer 74: 102-111, 1997
99) Caligo MA, Bellachene A, Cipollini G, Bevilacqua G, Castronovo V: Progestin but not retinoic acid stimulates BRCA1 mRNA expression in MCF7 human breast cancer cells. Int J Oncol 10: 253-256, 1997
100) Cipollini G, Berti A, Fiore L, Basolo F, Rainaldi G, Merlo G, Bevilacqua G, Caligo MA: Down regulation of NM23.H1 gene inhibits cell proliferation. Int J Cancer 73: 297-302, 1997
101) Viacava P, Naccarato AG, Bevilacqua G: Apocrine epithelium of the breast: does it result from metaplasia? Virchow Arch 431: 205-209, 1997
L. Publications: 102-115
102) Barbareschi M, Pelosio P, Caffo O, Buttitta F, Barbazza R, Dalla Palma P, Bevilacqua G, Marchetti A: Cyclin D1 gene amplification and expression in breast carcinoma: relation with clinicopathological characteristics and with retinoblastoma gene product, p53 and p21WAF1 immunohistochemical expression. Int J Cancer 74: 171-174, 1997103) Fontanini G, Lucchi M, Vignati S, Mussi A, Ciardiello F, De Laurentiis M, De Placido S, Basolo F, Angeletti CA, Bevilacqua G: Angiogenesis as a prognostic indicator of survival in non small cell lung carcinoma: a prospective study. J Natl Cancer Inst 89: 881-886, 1997
104) Fontanini G, Vignati S, Boldrini L, Chinè S, Silvestri V, Lucchi M, Mussi A, Angeletti CA, Bevilacqua G: Vascular endothelial growth factor is associated with neovascularization and influences progression in Non Small Cell Lung Carcinoma (NSCLC). Clin Cancer Research 3: 861-865, 1997
105) Lucchi M, Fontanini G, Mussi A, Vignati S, Janni A, Chella A, Ribechini A, Menconi GF, Bevilacqua G, Angeletti CA: Tumor angiogenesis and biological markers in resected stage I NSCLC. Eur J Cardiothorac Surg 12: 535-541, 1997
106) Fontanini G, Vignati S, Bigini D, Lucchi M, Mussi A, Chinè S, Angeletti CA, Basolo F, Bevilacqua G: Neoangiogenesis and p53 protein in lung cancer: their prognostic role and their relation with vascular endothelial growth factor (VEGF) expression. Br J Cancer 75, 1295-1301, 1997
107) Fontanini G, Vignati S, Chinè S, Lucchi M, Mussi A, Angeletti CA, Ménard S, Castronovo V, Bevilacqua G: 67-Kilodalton laminin receptor expression correlates with worse prognostic indicators in non small cell lung carcinomas. Clin Cancer Res 3: 227-231, 1997
108) Viacava P, Naccarato AG, Collecchi P, Ménard S, Castronovo V, Bevilacqua G: The spectrum of 67-kD laminin receptor expression in breast carcinoma progression. J Pathol 182: 36-44, 1997
109) Marchetti A, Buttitta F, Carnicelli V, Pellegrini S, Bertacca G, Bevilacqua G: Enriched SSCP: a highly sensitive method for the detection of alleles with unknown mutations. Diagn Mol Pathol 6: 185-191, 1997
110) Fontanini G, De Laurentiis M, Vignati S, Chine S, Lucchi M, Silvestri V, Mussi A, De Placido S, Tortora G, Bianco AR, Gullick W, Angeletti CA, Bevilacqua G, Ciardiello F: Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer: amphiregulin and microvessel count are independent prognostic indicators of survival. Clin Cancer Res 4: 241-249, 1998
111) Fontanini G, Boldrini L, Vignati S, Chine S, Basolo F, Silvestri V, Lucchi M, Mussi A, Angeletti CA, Bevilacqua G: Bcl2 and p53 regulate vascular endothelial growth factor (VEGF)-mediated angiogenesis in non-small cell lung carcinoma. Eur J Cancer 34: 718-723, 1998
112) Fontanini G, Del Mastro L, Bevilacqua G: Determination of angiogenesis in human neoplasms: current prognostic and therapeutic implications. Forum 8: 128-142, 1998
113) Collecchi P, Baldini E, Giannessi P, Naccarato AG, Passoni A, Gardin G, Roncella M, Evangelista G, Bevilacqua G, Conte PF: Primary chemotherapy in locally advanced breast cancer (LABC): effects on tumour proliferative activity, bcl-2 expression and the relationship between tumour regression and biological markers. Eur J Cancer 34: 1701-1704, 1998
114) Viacava P, Naccarato AG, Bevilacqua G: Spectrum of GCDFP-15 expression in human fetal and adult normal tissues. Virchows Arch 432: 255-260, 1998
115) Caligo MA, Polidoro L, Ghimenti C, Campani D, Cecchetti D, Bevilacqua G: A region on the long arm of chromosome 16 is frequently deleted in metastatic node-negative breast cancer. Int J Oncol 13: 177-182, 1998
L. Publications: 116-130
116) Caligo MA, Ghimenti C, Marchetti A, Lonobile A, Buttitta F, Pellegrini S, Bevilacqua G: Microsatellite alterations and p53, TGFbetaRII, IGFIIR and BAX mutations in sporadic non-small-cell lung cancer. Int J Cancer 78: 606-609, 1998117) Galimberti S, Marchetti A, Buttitta F, Carnicelli V, Pellegrini S, Bevilacqua G, Petrini M: Multidrug resistance related genes and p53 expression in human non small cell lung cancer. Anticancer Res 18: 2973-2976, 1998
118) Marchetti A, Pellegrini S, Sozzi G, Bertacca G, Gaeta P, Buttitta F, Carnicelli V, Griseri P, Chella A, Angeletti CA, Pierotti M, Bevilacqua G: Genetic analysis of lung tumours of non-smoking subjects: p53 gene mutations are constantly associated with loss of heterozygosity at the FHIT locus. Br J Cancer 78: 73-78, 1998
119) Marchetti A, Pellegrini S, Bertacca G, Buttitta F, Gaeta P, Carnicelli V, Nardini V, Griseri P, Chella A, Angeletti CA, Bevilacqua G: FHIT and p53 gene abnormalities in bronchioloalveolar carcinomas. Correlations with clinicopathological data and K-ras mutations. J Pathol 184: 240-246, 1998
120) Marchetti A, Doglioni C, Barbareschi M, Buttitta F, Pellegrini S, Gaeta P, La Rocca R, Merlo G, Chella A, Angeletti CA, Dalla Palma P, Bevilacqua G: Cyclin D1 and retinoblastoma susceptibility gene alterations in non-small cell lung cancer. Int J Cancer 75: 187-192, 1998
121) Giani C, Pinchera A, Rasmussen A, Fierabracci P, Bonacci R, Campini D, Bevilacqua G, Trock B, Lippman ME, Cullen KJ: Stromal IGF-II messenger RNA in breast cancer: relationship with progesterone receptor expressed by malignant epithelial cells. J Endocrinol Invest 21: 160-165, 1998
122) Indinnimeo M, Cicchini C, Stazi A, Mingazzini P, Caligo MA, Ghimenti C, Bevilacqua G: Genetic instability, p53 and nm23 mutation and clinicopathological features in rectal carcinoma. Anticancer Res 18: 989-993, 1998
123) Buttitta F, Marchetti A, Radi O, Bertacca G, Pellegrini S, Gadducci A, Genazzani AR, Bevilacqua G: Evaluation of FHIT gene alterations in ovarian cancer. Br J Cancer 77: 1048-1051, 1998
124) Gadducci A, Ferdeghini M, Buttitta F, Cosio S, Fanucchi A, Annicchiarico C, Gagetti O, Bevilacqua G, Genazzani AR: Assessment of the prognostic relevance of serum anti-p53 antibodies in epithelial ovarian cancer. Gynecol Oncol 72: 76-81, 1999
125) Hodgson S, Milner B, Brown I, Bevilacqua G, Chang-Claude J, Eccles D, Evans G, Gregory H, Moller P, Morrison P, Steel M, Stoppa-Lyonnet D, Vasen H, Haites N: Cancer genetics services in Europe. Dis Markers 15: 3-13, 1999
126) Moller P, Evans G, Haites N, Vasen H, Reis MM, Anderson E, Apold J, Hodgson S, Eccles D, Olsson H, Stoppa-Lyonnet D, Chang-Claude J, Morrison PJ, Bevilacqua G, Heimdal K, Maehle L, Lalloo F, Gregory H, Preece P, Borg A, Nevin NC, Caligo M, Steel CM: Guidelines for follow-up of women at high risk for inherited breast cancer: consensus statement from the Biomed 2 Demonstration Programme on Inherited Breast Cancer. Dis Markers 15: 207-211, 1999
127) Viacava P, Naccarato AG, Bevilacqua G: Different proliferative patterns characterize different preinvasive breast lesions. J Pathol 188: 245-251, 1999
128) Collecchi P, Passoni A, Rocchetta M, Gnesi E, Baldini E, Bevilacqua G: Cyclin-D1 expression in node positive (N+) and node negative (N-) infiltrating human mammary carcinomas. Int J Cancer, 84: 139-144, 1999
129) Penco S, Caligo MA, Cipollini G, Bevilacqua G, Garrè C: Lactoferrin expression in human breast cancer. Cancer Biochem Biophys 17: 163-178, 1999
130) Fontanini G, Boldrini L, Calcinai A, Chine S, Lucchi M, Mussi A, Angeletti CA, Basolo F, Bevilacqua G: Thrombospondins I and II messenger RNA expression in lung carcinoma: relationship with p53 alterations, angiogenic growth factors, and vascular density. Clin Cancer Res 5: 155-161, 1999
L. Publications: 131-147
131) Boldrini L, Calcinai A, Silvestri V, Basolo F, Lucchi M, Mussi A, Angeletti CA, Bevilacqua G, Fontanini G: Quantitation by competitive PCR assay of vascular endothelial growth factor in non-small cell lung carcinomas. Int J Oncol 14: 161-168, 1999132) Fontanini G, Boldrini L, Chine S, Pisaturo F, Basolo F, Calcinai A, Lucchi M, Mussi A, Angeletti CA, Bevilacqua G: Expression of vascular endothelial growth factor mRNA in non-small-cell lung carcinomas. Br J Cancer 79: 363-369, 1999
133) Campani D, Boggi U, Cecchetti D, Esposito I, Ceccarelli F, D'Antonio L, De Negri F, Mosca F, Bevilacqua G, Fornaciari G: p53 overexpression in lymph node metastases predicts clinical outcome in ductal pancreatic cancer. Pancreas 19: 26-32, 1999
134) Ghimenti C, Lonobile A, Campani D, Bevilacqua G, Caligo MA: Microsatellite instability and allelic losses in neuroendocrine tumors of the gastro-entero-pancreatic system. Int J Oncol 15: 361-366, 1999
135) Pellegrini S, Bertacca G, Buttitta F, Bevilacqua G, Marchetti A: Lung tumours from non-smoking subjects: A p53-related genetic instability in a subset of cases. Int J Mol Med 4: 419-424, 1999
136) Marchetti A, Bertacca G, Buttitta F, Chella A, Quattrocolo G, Angeletti CA, Bevilacqua G: Telomerase activity as a prognostic indicator in stage I non-small cell lung cancer. Clin Cancer Res 5: 2077-2081, 1999
137) Bevilacqua G: Cancer as a genetic event. In: Greggi S, Mancuso S, Pecorelli S: Familial and Hereditary cancer in women. Poletto, 1-9, 1999
138) Bevilacqua G, Naccarato AG: Morfologia del danno da alcool etilico. In: Cassano GB et al: Trattato Italiano di Psichiatria, Masson, 1469-1474, 1999
139) Campani D, Caligo MA, Esposito I, Bevilacqua G: Epidemiology and Pathology of Liver Metastasis. In: Bartolozzi G, Lencioni R: Liver Malignancies. Springer Verlag, 1999
140) Ghimenti C, Tannergard P, Wahlberg S, Liu T, Giulianotti P, Mosca F, Fornaciari G, Bevilacqua G, Lindblom A, Caligo MA: Microsatellite instability and mismatch repair gene inactivation in sporadic pancreatic and colon tumors. Br J Cancer, 80: 11-16, 1999
141) Bevilacqua G, Giavazzi R, Lollini PL: Invasione e Metastasi. Pacini, 1999
142) Di Paolo A, Danesi R, Nardini D, Bocci G, Innocenti F, Fogli S, Barachini S, Marchetti A, Bevilacqua G, Del Tacca M: Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumor cells. Br J Cancer 82: 905-912, 2000
143) Caligo MA, Ghimenti C, Sensi E, Marchetti A, Bertacca G, Giulianotti PG, Fornaciari G, Bevilacqua G: Microsatellite alterations and K-ras, TGFbetaRII, IGFRII and bax mutations in sporadic cancers of the gastrointestinal tract. Oncol Rep 7: 1371-1375, 2000
144) Cipollini G, Moretti M, Ghimenti C, Viacava P, Bevilacqua G, Caligo MA: Mutational analysis of NM23H1 gene in human breast cancer. Cancer Genet Cytogenet 121: 181-185 2000
145) Viacava P, Naccarato AG, Campani D, Collecchi P, Cipollini G, Caligo MA, Bevilacqua G: Guidelines for diagnosis and characterization of breast tumors. CME J Gynecol Oncol 5: 241-242, 2000
146) Hodgson S, Milner B, Brown I, Gregory H, Bevilacqua G, Haites N, Eccles D, Evans G, Møller P, Stoppa-Lyonnet D, Chang Claude J, Caligo MA, Morrison P, Steel M, Vasen H: Clinical service development for familial breast cancer in European Countries; the role and training of genetic councellors in this service, and educational provision in cancer genetics. CME J Gynecol Oncol 5: 261-268, 2000
147) Møller P, Evans G, Haites NE, Vasen H, Reis MM, Andersonk E, Apold J, Hodgson S, Eccles DM, Olsson H, Stoppa-Lyonnet D, Chang-Claude J, Morrison PJ, Bevilacqua G, Heimdal K, Mahle L, Lalloo F, Gregory H, Preece P, Borg A, Nevin NC, Caligo M, Steel M: Women at risk for inherited breast or ovarian cancer: guidelines for follow-up. CME J Gynecol Oncol 5: 269-271, 2000
L. Publications: 148-158
148) Steel CM, Morrison PJ, Møller P, Evans G, Haites NE, Vasen H, Hodgson S, Eccles D, Stoppa-Lyonnet D, Chang-Claude J, Bevilacqua G: Familial breast cancer: some social, economic and ethical issues. CME J Gynecol Oncol 5: 278-286, 2000149) Naccarato AG, Viacava P, Vignati S, Fanelli G, Bonadio A, Bevilacqua G: Bio-morphological events in the development of the human female mammary gland from fetal age to puberty. Virchows Arch 436: 431-438, 2000
150) Collecchi P, Santoni T, Gnesi E, Naccarato AG, Passoni A, Rocchetta M, Danesi R, Bevilacqua G: The cyclins of phases G1, S and G2/M are overexpressed in aneuploid mammary carcinomas. Cytometry 42: 254-260, 2000
151) Marchetti A, Buttitta F, Bertacca G, Zavaglia K, Bevilacqua G, Angelucci D, Viacava P, Naccarato A, Bonadio A, Barassi F, Felicioni L, Salvatore S, Mucilli F: mRNA markers of breast cancer nodal metastases: comparison between mammaglobin and carcinoembryonic antigen in 248 patients. J Pathol 195: 186-190, 2001
152) Paradiso A, Ranieri G, Silvestris N, Naccarato G, Bevilacqua G, Mangia A, Leone B, Vallejo C, Simone G, Schittulli F, De Lena M: Failure of primary breast cancer neoangiogenesis to predict pattern of distant metastasis. Clin Exp Med 1: 127-132, 2001
153) Campani D, Esposito I, Boggi U, Cecchetti D, Menicagli M, De Negri F, Colizzi L, Del Chiaro M, Mosca F, Fornaciari G, Bevilacqua G: Bcl-2 expression in pancreas development and pancreatic cancer progression. J Pathol 194: 443-449, 2001
154) Ghimenti C, Sensi E, Presciuttini S, Brunetti IM, Conte P, Bevilacqua G, Caligo MA: Germline mutations of the BRCA1-associated ring domain (BARD1) gene in breast and breast/ovarian families negative for BRCA1 and BRCA2 alterations. Genes Chromosomes Cancer 33: 235-242, 2002
155) Giani C, Campani D, Rasmussen A, Fierabracci P, Miccoli P, Bevilacqua G, Pinchera A, Cullen KJ: Insulin-like growth factor II (IGF-II) immunohistochemistry in breast cancer: relationship with the most important morphological and biochemical prognostic parameters. Int J Biol Markers 17: 90-95, 2002
156) Paradiso A, Volpe S, Iacobacci A, Marubini E, Verderio P, Costa A, Daidone MG, Marchetti A, Mottolese M, Amadori D, De Paola F, Saragoni L, Medri L, Nenci I, Querzoli P, Gion M, Dittadi R, Plebani M, Orlando C, Bevilacqua G, Silvestrini R; Italian Network for Quality Assessment of Tumor Biomarkers: Quality control for biomarker determination in oncology: the experience of the Italian Network for Quality Assessment of Tumor Biomarkers (INQAT). Int J Biol Markers 17: 201-214, 2002
157) Esposito I, Kleeff J, Bischoff SC, Fischer L, Collecchi P, Iorio M, Bevilacqua G, Buchler MW, Friess H: The Stem Cell Factor-c-kit System and Mast Cells in Human Pancreatic Cancer. Lab Invest 82: 1481-1492, 2002
158) Cilotti A, Caligo MA, Cipollini G, Francesca D, Marini C, Moretti M, Roncella M, Bartolozzi C, Bevilacqua G: Breast MR imaging screening in eight women proved or suspected to be carriers of BRCA1&2 gene mutations. J Exp Clin Cancer Res 21 (3 Suppl): 137-40, 2002
L. Publications: 159-169
159) Podo F, Sardanelli F, Canese R, D'Agnolo G, Natali PG, Crecco M, Grandinetti ML, Musumeci R, Trecate G, Bergonzi S, De Simone T, Costa C, Pasini B, Manuokian S, Spatti GB, Vergnaghi D, Morassut S, Boiocchi M, Dolcetti R, Viel A, De Giacomi C, Veronesi A, Coran F, Silingardi V, Turchett D, Cortesi L, De Santis M, Federico M, Romagnoli R, Ferrari S, Bevilacqua G, Bartolozzi C, Caligo MA, Cilotti A, Marini C, Cirillo S, Marra V, Martincich L, Contegiacomo A, Pensabene M, Capuano I, Burgazzi GB, Petrillo A, Bonomo L, Carriero A, Mariani-Costantini R, Battista P, Cama A, Palca G, Di Maggio C, D'Andrea E, Bazzocchi M, Francescutti GE, Zuiani C, Londero V, Zunnui I, Gustavino C, Centurioni MG, Iozzelli A, Panizza P, Del Maschio A: The Italian multi-centre project on evaluation of MRI and other imaging modalities in early detection of breast cancer in subjects at high genetic risk. J Exp Clin Cancer Res 21 (3 Suppl): 115-24, 2002160) Aretini P, D'Andrea E, Pasini B, Viel A, Mariani Costantini R, Cortesi L, Agata S, Bisegna R, Boiocchi M, Caligo MA, Chieco-Bianchi L, Cipollini G, Crucianelli R, D'Amico C, Federico M, Ghimenti C, De Giacomi C, De Nicolo A, Della Puppa L, Ferrari S, Ficorella C, Iandolo D, Manoukian S, Marchetti P, Marroni F, Menin C, Montagna M, Ottini L, Pensotti V, Pienotti M,
Radice P, Ricevuto E, Santarosa M, Silingardi V, Turchetti D, Bevilacqua G, Presciuttini S: Different expressivity of brca1 and brca2: analysis of 179 italian pedigrees with identified mutation. Breast Cancer Res Treat. 81: 71-79, 2003
161) Chaplet M, De Leval L, Waltregny D, Detry C, Fornaciari G, Bevilacqua G, Fisher LW, Castronovo V, Bellahcene A: Dentin matrix protein 1 is expressed in human lung cancer.
J Bone Miner Res: 18: 1506-1512, 2003
162) Naccarato AG, Viacava P, Bocci G, Fanelli G, Aretini P, Lonobile A, Montruccoli G, Bevilacqua G: Definition of the microvascular pattern of the normal human adult mammary gland. J Anat 203: 599-603, 2003
163) Sensi E, Tancredi M, Aretini P, Cipollini G, Naccarato AG, Viacava P, Bevilacqua G, Caligo MA: p53 inactivation is a rare event in familial breast tumors negative for BRCA1 and BRCA2 mutations. Breast Cancer Res Treat 82: 1-9, 2003
164) Marroni F, Aretini P, D'Andrea E, Caligo MA, Cortesi L, Viel A, Ricevuto E, Montagna M, Cipollini G, Ferrari S, Santarosa M, Bisegna R,. Bailey-Wilson JE, Bevilacqua G, Parmigiani G, Presciuttini S: Evaluation of widely used models for predicting BRCA1 and BRCA2 mutations. J Med Genetics, 41: 278-285, 2004
165) Mazzanti C, Zeiger MA, Costourous N, Umbricht C, Westra WH, Smith D, Somervell H, Bevilacqua G, Alexander HR, Libutti SK: Using Gene Expression Profiling to Differentiate Benign versus Malignant Thyroid Tumors. Cancer Res 64: 2898-2903, 2004
166) Esposito I, Menicagli M, Funel N, Bergmann F, Mosca F, Boggi U, Bevilacqua G, Campani D: Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma. J Clin Pathol 57: 630-636, 2004
167) Cipollini G, Tommasi S, Paradiso A, Aretini P, Bonatti F, Brunetti I, Bruno M, Lombardi G, Schittulli F, Sensi E, Tancredi M, Bevilacqua G, Caligo MA: Genetic alterations in hereditary breast cancer. Ann Oncol 15: I7-I13, 2004
168) Mazzanti CM, Tandle A, Lorang D, Costouros N, Roberts D, Bevilacqua G, Libutti SK: Early genetic mechanisms underlying the inhibitory effects of endostatin and fumagillin on human endothelial cells. Genome Res 14:1585-1593, 2004
169) Tancredi M, Sensi E, Cipollini G, Aretini P, Lombardi G, Di Cristofano G, Presciuttini S, Bevilacqua G, Caligo MA: Haplotype analysis of BRCA1 gene reveals a new gene rearrangement: characterization of a 19.9 kbp deletion. European J Human Genet 12: 775-777, 2004
L. Publications: 170-183
170) Sensi E, Tancredi M, Aretini P, Cipollini G, Collecchi P, Naccarato AG, Viacava P, Bevilacqua G, Caligo MA: Clinicopathological significance of GADD45 gene alterations in human familial breast carcinoma. Breast Cancer Res Treat 87: 197-201, 2004171) Bocci G, Danesi R, Marangoni G, Fioravanti A, Boggi U, Esposito I, Fasciani A, Boschi E, Campani D, Bevilacqua G, Mosca F, Del Tacca M: Antiangiogenic versus cytotoxic therapeutic approaches to human pancreas cancer: an experimental study with a vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor and gemcitabine. Eur J Pharmacol 498: 9-18, 2004
172) Viacava P, Naccarato AG, Bocci G, Fanelli G, Aretini P, Lonobile A, Evangelista G, Montruccoli GC, Bevilacqua G: Angiogenesis and VEGF expression in preinvasive lesions of the human breast. J Pathol 204: 140-146, 2004
173) Marroni F, Aretini P, D'Andrea E, Caligo MA, Cortesi L, Viel A, Ricevuto E, Montagna M, Cipollini G, Federico M, Santarosa M, Marchetti P, Bailey-Wilson JE, Bevilacqua G, Parmigiani G, Presciuttini S: Penetrances of breast and ovarian cancer in a large series of families tested for BRCA1/2 mutations. European J Human Genet 12: 899-906, 2004
174) Di Cristofano C, Mrad K, Zavaglia K, Bertacca G, Aretini P, Cipollini G, Bevilacqua G, Romdhane KB, Cavazzana A: Papillary lesions of the breast: a molecular progression? Breast Cancer Res Treat 90: 71-6, 2005
175) Minervini A, Di Cristofano C, Collecchi P, Salinitri G, Selli C, Bevilacqua G, Minervini R, Cavazzana A: Intracapsular clear cell renal carcinoma: ploidy status improves the prognostic value of the 2002 TNM classification. J Urol 174: 1203-1207, 2005
176) Giovannetti E, Del Tacca M, Mey V, Funel N, Nannizzi S, Ricci S, Orlandini C, Boggi U, Campani D, Del Chiaro M, Iannopollo M, Bevilacqua G, Mosca F, Danesi R: Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine. Cancer Res 66: 3928-3935, 2006
177) Gadducci A, Di Cristofano C, Zavaglia M, Giusti L, Menicagli M, Cosio S, Naccarato AG, Genazzani AR, Bevilacqua G, Cavazzana AO: P53 gene status in patients with advanced serous epithelial ovarian cancer in relation to response to paclitaxel- plus platinum-based chemotherapy and long-term clinical outcome. Anticancer Res 26: 687-693, 2006
178) Carpi A, Naccarato AG, Iervasi G, Nicolini A, Bevilacqua G, Viacava P, Collecchi P, Lavra L, Marchetti C, Sciacchitano S, Bartolazzi A: Large needle aspiration biopsy and galectin-3 determination in selected thyroid nodules with indeterminate FNA-cytology. Br J Cancer 95: 204-209, 2006
179) Viacava P, Bocci G, Fanelli C, Cetani F, Marcocci C, Bevilacqua G, Naccarato AG: Microvessel density in human normal and neoplastic parathyroids. Endocrine Pathol 17: 175-181, 2006
180) Marchetti I, Zavaglia K, Bertacca G, Aretini P, Matteoli B, Viacava P, Prato B, De Punzio C, Genazzani AR, Bevilacqua G, Di Coscio G: HPV testing and PAP test: role for a combined approach in a non-screened population. Int J Biol Markers 21: 149-156, 2006
181) Zammarchi F, Pistello M, Piersigilli A, Murr R, Di Cristofano C, Naccarato AG, Bevilacqua G: MMTV-like sequences in human breast cancer: a fluorescent PCR / laser microdissection approach. J Pathol 209: 436-444, 2006
182) Bonatti F, Pepe C, Tancredi M, Lombardi G, Aretini A, Sensi E, Falaschi E, Cipollini G, Bevilacqua G, Caligo MA: RNA based analysis of BRCA and BRCA gene alterations. Cancer Genet Cytogen 170: 93-101, 2006
183) Di Cosmo C, Fanelli G, Tonacchera M, Ferrarini E, Dimida A, Agretti P, De Marco G, Vitti P, Pinchera A, Bevilacqua G, Naccarato AG, Viacava P: The sodium-iodide symporter expression in placental tissue at different gestational age: an immunohistochemical study. Clin Endocrinol 65: 544-548, 2006
L. Publications: 184-196
184) Baldini E, Camerini A, Sgambato A, Prochilo T, Capodanno A, Pasqualetti F, Orlandini C, Resta L, Bevilacqua G, Collecchi P: Cyclin A and E2F1 overexpression correlate with reduced disease-free survival in node-negative breast cancer patients. Anticancer Res 26: 4415-4421, 2006185) Pepe C, Guidugli L, Sensi E, Aretini P, D'Andrea E, Montagna M, Manoukian S, Ottini L, Radice P, Viel A, Bevilacqua G, Caligo MA: Methyl group metabolism gene polymorphisms as modifier of breast cancer risk in italian BRCA 1/2 carriers. Breast Cancer Res Treat 103: 29-36, 2007
186) Lombardi G, Di Cristofano C, Capodanno A, Iorio MC, Aretini P, Isola I, Tancredi M, Collecchi P, Naccarato AG, Prosperi Porta R, Bevilacqua G, Caligo MA: High level of messenger RNA for BRMS1 in primary breast carcinomas is associated with poor prognosis. Int J Cancer 120: 1169-1178, 2007
187) Lombardi G, Falaschi E, Sensi E, Naccarato AG, Di Cristofano C, Aretini P, Bevilacqua G, Caligo MA: Identification of novel alternatively spliced bard1 (brca-associated ring domain) messenger RNAs in human peripheral blood lymphocytes and in sporadic breast cancer tissues. Gene Chromosome Canc 46: 791-795, 2007
188) Dell'Atti D, Zavaglia M, Tombelli S, Bertacca G, Cavazzana AO, Bevilacqua G, Minunni M, Mascini M: Development of combined DNA-based piezoelectric biosensors for the simultaneous detection and genotyping of high risk Human Papilloma Virus strains. Clin Chim Acta 383: 140-146, 2007
189) Viacava P, Bocci G, Tonacchera M, Fanelli G, DeServi M, Agretti P, Berti E, Goletti O, Aretini P, Resta ML, Bevilacqua G, Naccarato AG: Markers of cell proliferation, apoptosis, and angiogenesis in thyroid adenomas: a comparative immunohistochemical and genetic investigation of functioning and nonfunctioning nodules. Thyroid 17:191-197, 2007
190) Cilotti A, Iacconi C, Marini C, Moretti M, Mazzotta D, Traino C, Naccarato AG, Piagneri V, Giaconi C, Bevilacqua G, Bartolozzi C: Contrast-enhanced MR imaging in patients with BI-RADS 3-5 microcalcifications. Radiol Med 112: 272-286, 2007
191) Gargani L, Lionetti V, Di Cristofano C, Bevilacqua G, Recchia FA, Picano E: Early detection of acute lung injury uncoupled to hypoxemia in pigs using ultrasound lung comets. Crit Care Med 35: 2769-2774 , 2007
192) Mazzeo S, Cappelli C, Caramella D, Del Chiaro M, Campani D, Pollina L, Caproni G, Battaglia V, Belcari A, Funel N, Di Candio G, Forasassi F, Boggi U, Bevilacqua G, Mosca F, Bartolozzi C: Evaluation of vascular infiltration in resected patients for pancreatic cancer: comparison among multidetector CT, intraoperative findings and histopathology. Abdom Imaging 32: 737-742, 2007
193) Di Cristofano C, Minervini A, Menicagli M, Salinitri G, Bertacca G, Pefanis G, Masieri L, Lessi F, Collecchi P, Minervini R, Carini M, Bevilacqua G, Cavazzana A: Nuclear Expression of Hypoxia-inducible Factor-1alpha in Clear Cell Renal Cell Carcinoma is Involved in Tumor Progression. Am J Surg Pathol 31: 1875-1881, 2007
194) Prato B, Ghelardi A, Gadducci A, Marchetti I, Di Cristofano C, Di Coscio G, Bevilacqua G, Genazzani AR: Correlation of recurrence rates and times with posttreatment human papillomavirus status in patients treated with loop electrosurgical excision procedure conization for cervical squamous intraepithelial lesions. Int J Gynecol Cancer 18: 90-94, 2008
195) Theodosiou Z, Kasampalidis IN, Karayannopoulou G, Kostopoulos I, Bobos M, Bevilacqua G, Aretini P, Starita A, Lyroudia K, Pitas I: Evaluation of FISH image analysis system on assessing HER2 amplification in breast carcinoma cases. Breast 17: 80-84, 2008
196) Pifferi M, Maggi F, Cristofano CD, Cangiotti AM, Nelli LC, Bevilacqua G, Macchia P, Bendinelli M, Boner AL: Torquetenovirus Infection and Ciliary Dysmotility in Children With Recurrent Pneumonia. Pediatr Infect Dis J 27: 413-418, 2008
L. Publications: 197-210
197) Becherini F, Castagna M, Iannelli A, Favre C, Abbruzzese A, Caligo MA, Bertacca G, Pingitore R, Bevilacqua G, Cavazzana AO: Choroid plexus carcinoma: a new case associated with a novel TP53 germ line mutation. Neuropathol Appl Neurobiol 34: 564-568, 2008198) Marroni F, Cipollini G, Peissel B, D'Andrea E, Pensabene M, Radice P, Caligo MA, Presciuttini S, Bevilacqua G: Reconstructing the Genealogy of a BRCA1 Founder Mutation by Phylogenetic Analysis. Ann Hum Genet 72: 310-318, 2008
199) van Krieken JH, Jung A, Kirchner T, Carneiro F, Seruca R, Bosman FT, Quirke P, Fléjou JF, Plato Hansen T, de Hertogh G, Jares P, Langner C, Hoefler G, Ligtenberg M, Tiniakos D, Tejpar S, Bevilacqua G, Ensari A: KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program. Virchows Arch 453: 417-431, 2008
200) Bevilacqua G, Inghirami G: Collection, banking and diagnostic archiving of tissues. Pathologica. 100: 49-54, 2008
201) Minervini A, Di Cristofano C, Gacci M, Serni S, Menicagli M, Lanciotti M, Salinitri G, Rocca CD, Lapini A, Nesi G, Bevilacqua G, Minervini R, Carini M: Prognostic role of histological necrosis for nonmetastatic clear cell renal cell carcinoma: correlation with pathological features and molecular markers. J Urol 180: 1284-1289 2008
202) Nemolato S, Fanni D, Naccarato AG, Ravarino A, Bevilacqua G, Faa G: Lymphoepitelioma-like hepatocellular carcinoma: A case report and a review of the literature.World J Gastroenterol. 14: 4694-6, 2008
203) De Nicolo A, Tancredi M, Lombardi G, Flemma CC, Barbuti S, Di Cristofano C, Sobhian B, Bevilacqua G, Drapkin R, Caligo MA: A novel breast cancer-associated BRIP1 (FANCJ/BACH1) germ-line mutation impairs protein stability and function. Clin Cancer Res 14: 4672-4680, 2008
204) Funel N, Giovannetti E, Del Chiaro M, Mey V, Pollina LE, Nannizzi S, Boggi U, Ricciardi S, Del Tacca M, Bevilacqua G, Mosca F, Danesi R, Campani D: Laser microdissection and primary cell cultures improve pharmacogenetic analysis in pancreatic adenocarcinoma. Lab Invest 88: 773-784, 2008
205) Bevilacqua G: Stromal tumours: which diagnostic approach ? J Clin Pathol 62: 289, 2009
206) Chifenti B, Morelli M, Zavaglia M, Coviello DA, Guerneri S, Santucci A, Paffetti A, Masetti M, Locci MT, Bertacca G, Capodanno A, Collecchi P, Campani D, Mosca F, Bevilacqua G, Cavazzana AO: Establishment and Characterization of 4 New Human Pancreatic Cancer Cell Lines: Evidences of Different Tumor Phenotypes. Pancreas, 38: 184-196, 2009
207) Pensabene M, Spagnoletti I, Capuano I, Condello C, Pepe S, Contegiacomo A, Lombardi G, Bevilacqua G, Caligo MA: Two mutations of BRCA2 gene at exon and splicing site in a woman who underwent oncogenetic counseling. Ann Oncol 20: 874-878, 2009
208) Sgambato A, Camerini A, Collecchi P, Graziani C, Bevilacqua G, Capodanno A, Migaldi M, Masciullo V, Scambia G, Rossi G, Cittadini A, Amoroso D. Cyclin E correlates with manganese superoxide dismutase expression and predicts survival in early breast cancer patients receiving adjuvant epirubicin-based chemotherapy. Cancer Sci 100: 1026-1033, 2009
209) Capodanno A, Camerini A, Orlandini C, Baldini E, Resta ML, Bevilacqua G, Collecchi P: Dysregulated PI3K/Akt/PTEN pathway is a marker of a short disease-free survival in node-negative breast carcinoma. Hum Pathol 40: 1408-1417 2009
210) Marchetti I, Lessi F, Mazzanti CM, Bertacca G, Elisei R, Di Coscio G, Pinchera A, Bevilacqua G: A Morpho-Molecular Diagnosis of Papillary Thyroid Carcinoma: BRAF V600E Detection as an Important Tool in Preoperative Evaluation of Fine-Needle Aspirates. Thyroid 19: 837-842 2009
L. Publications: 211-
211) Minervini A, di Cristofano C, Lapini A, Marchi M, Lanzi F, Giubilei G, Tosi N, Tuccio A, Mancini M, Della Rocca C, Serni S, Bevilacqua G, Carini M: Histopathologic Analysis of Peritumoral Pseudocapsule and Surgical Margin Status after Tumor Enucleation for Renal Cell Carcinoma. Eur Urol 55: 1410-1418, 2009212) Vannucci L, Chiuppesi F, di Martino F, Caligo MA, Bevilacqua G, Pistello M: Feline immunodeficiency virus vector as a tool for preventative strategies against human breast cancer. Vet Immunol Immunopathol. Vet Immunol Immunopathol 134: 132-137, 2010
213) Lupi I, Manetti L, Caturegli P, Menicagli M, Cosottini M, Iannelli A, Acerbi G, Bevilacqua G, Bogazzi F, Martino E: Tumor Infiltrating Lymphocytes But Not Serum Pituitary Antibodies Are Associated with Poor Clinical Outcome after Surgery in Patients with Pituitary Adenoma. J Clin Endocrinol Metab. J Clin Endocrinol Metab 95: 289-296, 2010
214) Michelucci A, Di Cristofano C, Lami A, Collecchi P, Caligo A, Decarli N, Leopizzi M, Aretini P, Bertacca G, Porta RP, Ricci S, Rocca CD, Stanta G, Bevilacqua G, Cavazzana A: PIK3CA in Breast Carcinoma: A Mutational Analysis of Sporadic and Hereditary Cases. Diagn Mol Pathol. Diagn Mol Pathol, 18: 200-205, 2009
215) Elisei R, Molinaro E, Agate L, Bottici V, Masserini L, Ceccarelli C, Lippi F, Grasso L, Basolo F, Bevilacqua G, Miccoli P, Di Coscio G, Vitti P, Pacini F, Pinchera A: Are the Clinical and Pathological Features of Differentiated Thyroid Carcinoma Really Changed over the Last 35 Years? Study on 4187 Patients from a Single Italian Institution to Answer this Question. J Clin Endocrinol Metab. Epub ahead of print 2010
216) Bevilacqua G, Bosman F, Dassesse T, Höfler H, Janin A, Langer R, Larsimont D, Morente MM, Riegman P, Schirmacher P, Stanta G, Zatloukal K, Caboux E, Hainaut P: The role of the pathologist in tissue banking: European Consensus Expert Group Report. Virchows Arch. Epub ahead of print 2010